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Microbiological, Clinical, and PK/PD Features of the New Anti-Gram-Negative Antibiotics: β-Lactam/β-Lactamase Inhibitors in Combination and Cefiderocol—An All-Inclusive Guide for Clinicians

Articolo
Data di Pubblicazione:
2022
Abstract:
Bacterial resistance mechanisms are continuously and rapidly evolving. This is particularly true for Gram-negative bacteria. Over the last decade, the strategy to develop new beta-lactam/beta-lactamase inhibitors (BLs/BLIs) combinations has paid off and results from phase 3 and real-world studies are becoming available for several compounds. Cefiderocol warrants a separate discussion for its peculiar mechanism of action. Considering the complexity of summarizing and integrating the emerging literature data of clinical outcomes, microbiological mechanisms, and pharmacokinetic/pharmacodynamic properties of the new BL/BLI and cefiderocol, we aimed to provide an overview of data on the following compounds: aztreonam/avibactam, cefepime/enmetazobactam, cefepime/taniborbactam, cefepime/zidebactam, cefiderocol, ceftaroline/avibactam, ceftolozane/tazobactam, ceftazidime/avibactam, imipenem/relebactam, meropenem/nacubactam and meropenem/vaborbactam. Each compound is described in a dedicated section by experts in infectious diseases, microbiology, and pharmacology, with tables providing at-a-glance information.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
cefiderocol; pharmacodynamics; pharmacokinetics; β-lactamase inhibitors; β-lactams
Elenco autori:
Principe, Luigi; Lupia, Tommaso; Andriani, Lilia; Campanile, Floriana; Carcione, Davide; Corcione, Silvia; De Rosa, Francesco; Luzzati, Roberto; Stroffolini, Giacomo; Steyde, Marina; Decorti, Giuliana; Di Bella, Stefano
Autori di Ateneo:
CORCIONE Silvia
DE ROSA Francesco Giuseppe
Link alla scheda completa:
https://iris.unito.it/handle/2318/1992415
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1992415/1332641/pharmaceuticals-15-00463.pdf
Pubblicato in:
PHARMACEUTICALS
Journal
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Settori (9)


LS6_6 - Infectious diseases - (2022)

CIBO, AGRICOLTURA e ALLEVAMENTI - Farmacologia Veterinaria

CIBO, AGRICOLTURA e ALLEVAMENTI - Patologia e malattie degli animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Scienze cliniche veterinarie

MEDICINA, SALUTE e BENESSERE - Epidemiologia

MEDICINA, SALUTE e BENESSERE - Oncologia e Tumori

MEDICINA, SALUTE e BENESSERE - Ricerca Traslazionale e Clinica

MEDICINA, SALUTE e BENESSERE - Trapianti e medicina rigenerativa

SCIENZE DELLA VITA e FARMACOLOGIA - Interazioni tra molecole, cellule, organismi e ambiente
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