Skip to Main Content (Press Enter)

Logo UNITO
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione

UNI-FIND
Logo UNITO

|

UNI-FIND

unito.it
  • ×
  • Home
  • Pubblicazioni
  • Progetti
  • Persone
  • Competenze
  • Settori
  • Strutture
  • Terza Missione
  1. Pubblicazioni

The synaptic proteins Neurexins and Neuroligins are widely expressed in the vascular system and contribute to its functions

Articolo
Data di Pubblicazione:
2009
Abstract:
Unlike other neuronal counterparts, primarysynaptic proteins are not known to be involved invascular physiology.Here, we demonstrate that Neurexins and Neuroligins, whichconstitute large and complex families of fundamental players in synaptic activity,are produced and processed by endothelial and vascular smooth muscle cells throughout the vasculature. Moreover, they are dynamically regulated during vessel remodeling and form endogenous complexes in large vessels as well as in the brain. We then used the chicken chorioallantoic membrane as a system to pursue functional studies and demonstrate that a monoclonal recombinant antibody against beta Neurexin inhibits angiogenesis while exogenous Neuroligin has a role in promoting it. Finally, as an insight into the mechanism of action of betaNeurexin, we show that the anti beta NRXN antibody influences vessel tone in isolated chicken arteries. Ourdiscovery strongly supportsthe idea that even the mostcomplex and plasticeventstaking place inthe nervous system, i.e. synaptic activity, share molecular cues with the vascular system.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Angiogenesis; vascula tone
Elenco autori:
Bottos A; Destro E; Rissone A; Graziano S; Cordara ; Assenzio B; Cera MR ; Mascia L; Bussolino F; Arese M
Autori di Ateneo:
ARESE Marco
Link alla scheda completa:
https://iris.unito.it/handle/2318/60623
Pubblicato in:
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Journal
  • Utilizzo dei cookie

Realizzato con VIVO | Designed by Cineca | 25.6.1.0