The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis.
Articolo
Data di Pubblicazione:
2004
Abstract:
The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides eIF-4E-induced cellular senescence, whereas eIF-4E antagonizes c-Myc-dependent apoptosis in vivo. Our results implicate activation of eIF-4E as a key event in oncogenic transformation by phosphoinositide-3 kinase and Akt.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Animals; Apoptosis; Cocarcinogenesis; Eukaryotic Initiation Factor-4E; Gene Expression; Genes; myc; Lymphoma; B-Cell; Mice; Transgenic; Protein Kinases
Elenco autori:
D. Ruggero;L. Montanaro;L. Ma;W. Xu;P. Londei;C. Cordon-Cardo;P. P. Pandolfi
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