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Inflammation and Prostate Cancer: Pathological Analysis from Pros-IT CNR 2

Articolo
Data di Pubblicazione:
2023
Abstract:
Background: Extensive research effort has been devoted to investigating the link between inflammation and PCa. However, this relationship remains unclear and controversial. The aim of our multi-center study was to investigate this association by histologically evaluating the distribution of PI and PCA in prostate biopsy cores from patients of eight referral centers in Italy. Results: We evaluated 2220 cores from 197 patients; all the frustules were re-evaluated by dedicated pathologists retrospectively. Pathologists assigned IRANI scores and determined the positions of PIs; pathologists also re-evaluated the presence of PCa and relative ISUP grade. PCa was recorded in 749/2220 (33.7%). We divided this sample into a PCa PI group (634/749 cores [84.7%]) and a non-PCa + PI group (1157/1471 cores [78.7%]). We observed a statistically significant difference in the presence of inflammation among cores with cancer (p < 0.01). Moreover, periglandular inflammation was higher in the cores with neoplasia, while stromal inflammation was higher in cores without neoplasia (38.5% vs. 31.1% and 55.4% vs. 63.5% p < 0.01). Conclusions: In our experience, there is evidence of an association between PI and PCa at a tissue level. Further studies are needed to confirm our findings and to identify patients who might benefit from target therapies to prevent PCa occurrence and/or progression.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
prostate biopsy; prostate cancer; prostate inflammation
Elenco autori:
Sessa, Francesco; Nicoletti, Rossella; De Nunzio, Cosimo; Porreca, Angelo; Magrini, Stefano Maria; Mirone, Vincenzo; Tubaro, Andrea; Serni, Sergio; Gontero, Paolo; Noale, Marianna; Maggi, Stefania; Gacci, Mauro; null, null
Autori di Ateneo:
GONTERO Paolo
Link alla scheda completa:
https://iris.unito.it/handle/2318/2035677
Pubblicato in:
CANCERS
Journal
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