Expression of CD39 by human peripheral blood CD4+ CD25+ T cells denotes a regulatory memory phenotype
Articolo
Data di Pubblicazione:
2010
Abstract:
We have shown that CD39 and CD73 are coexpressed on the surface of murine CD4+ Foxp3+ regulatory T cells (Treg) and generate extracellular adenosine, contributing to Treg immunosuppressive activity. We now describe that CD39, independently of CD73, is expressed by a subset of blood-derived human CD4+ CD25+ CD127lo Treg, defined by robust expression of Foxp3. A further distinct population of CD4+ CD39+ T lymphocytes can be identified, which do not express CD25 and FoxP3 and exhibit the memory effector cellular phenotype. Differential expression of CD25 and CD39 on circulating CD4+ T cells distinguishes between Treg and pathogenic cellular populations that secrete proinflammatory cytokines such as IFNγ and IL-17. These latter cell populations are increased, with a concomitant decrease in the CD4+ CD25+ CD39+ Tregs, in the peripheral blood of patients with renal allograft rejection. We conclude that the ectonucleotidase CD39 is a useful and dynamic lymphocytes surface marker that can be used to identify different peripheral blood T cell-populations to allow tracking of these in health and disease, as in renal allograft rejection.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
CD4 regulatory cells; regulatory T cells; renal allograft; renal allograft rejection
Elenco autori:
Dwyer KM; Hanidziar D; Putheti P; Hill PA; Pommey S; McRae JL; Winterhalter A; Doherty G; Deaglio S; Koulmanda M; Gao W; Robson SC; Strom TB
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