Novel lymphocyte-independent antitumor activity by PD-1 blocking antibody against PD-1+ chemoresistant lung cancer cells
Articolo
Data di Pubblicazione:
2023
Abstract:
Antibodies against the lymphocyte PD-1 (aPD-1) receptor are cornerstone agents for advanced non-small cell lung cancer (NSCLC), based on their ability to restore the exhausted antitumor immune response. Our study reports a novel, lymphocyte independent, therapeutic activity of aPD-1 against NSCLC, blocking the tumor-intrinsic PD-1 receptors on chemoresistant cells.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
lymphocyte-independent, PD-1 blocking antibody against PD-1+, chemoresistant, lung cancer cells
Elenco autori:
Rotolo, Ramona; Leuci, Valeria; Donini, Chiara; Galvagno, Federica; Massa, Annamaria; De Santis, Maria Chiara; Peirone, Serena; Medico, Giovanni; Sanlorenzo, Martina; Vujic, Igor; Gammaitoni, Loretta; Basiricò, Marco; Righi, Luisella; Riganti, Chiara; Salaroglio, Iris Chiara; Napoli, Francesca; Tabbò, Fabrizio; Mariniello, Annapaola; Vigna, Elisa; Modica, Chiara; D'Ambrosio, Lorenzo; Grignani, Giovanni; Taulli, Riccardo; Hirsch, Emilio; Cereda, Matteo; Aglietta, Massimo; Scagliotti, Giorgio Vittorio; Novello, Silvia; Bironzo, Paolo; Sangiolo, Dario
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