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  1. Pubblicazioni

The Predictive Role of Extracellular NAPRT for the Detection of Advanced Fibrosis in Biopsy-Proven Non-Alcoholic Fatty Liver Disease

Articolo
Data di Pubblicazione:
2023
Abstract:
Intrahepatic oxidative stress is a key driver of inflammation and fibrogenesis in non-alcoholic fatty liver disease (NAFLD). We aimed to investigate the role of extracellular Nicotinamide phosphoribosyltransferase (eNAMPT) and extracellular nicotinic acid phosphoribosyltransferase (eNAPRT) for the detection of advanced fibrosis. eNAMPT and eNAPRT were tested in 180 consecutive biopsy-proven NAFLD patients and compared with liver stiffness (LS) and the FIB-4 score. eNAMPT was similarly distributed across fibrosis stages, whereas eNAPRT was increased in patients with advanced fibrosis (p = 0.036) and was associated with advanced fibrosis (OR 1.08, p = 0.016). A multiple stepwise logistic regression model containing significant variables for advanced fibrosis (eNAPRT, type 2 diabetes, age, male sex, ALT) had an area under the curve (AUC) of 0.82 (Se 89.6%, Sp 67.3%, PPV 46.7%, NPV 93.8%) when compared to that of LS (0.79; Se 63.5%, Sp 86.2%, PPV 66.0%, NPV 84.8%) and to that of the FIB-4 score (0.73; Se 80.0%, Sp 56.8%, PPV 44.9%, NPV 86.6%). The use of eNAPRT in clinical practice might allow for the better characterization of NAFLD patients at higher risk of disease progression.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
NAMPT; NAPRT; liver fibrosis; non-alcoholic fatty liver disease; non-alcoholic steatohepatitis; non-invasive tests; oxidative stress; visfatin
Elenco autori:
Armandi, Angelo; Colombo, Giorgia; Rosso, Chiara; Caviglia, Gian Paolo; Olivero, Antonella; Abate, Maria Lorena; Guariglia, Marta; Perez Diaz Del Campo, Nuria; Castelnuovo, Gabriele; Ribaldone, Davide Giuseppe; Saracco, Giorgio Maria; Genazzani, Armando A; Bugianesi, Elisabetta
Autori di Ateneo:
ARMANDI Angelo
BUGIANESI Elisabetta
CAVIGLIA Gian Paolo
GENAZZANI Armando
GUARIGLIA MARTA
OLIVERO Antonella
RIBALDONE Davide Giuseppe
ROSSO Chiara
Link alla scheda completa:
https://iris.unito.it/handle/2318/1886712
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/1886712/1092286/ijms-24-01172.pdf
Pubblicato in:
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Journal
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