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An Evaluation of the Effects of Pineapple-Extract and Bromelain-Based Treatment after Mandibular Third Molar Surgery: A Randomized Three-Arm Clinical Study

Articolo
Data di Pubblicazione:
2024
Abstract:
A three-arm, randomized, placebo-controlled clinical study was conducted to assess the impact of lyophilized pineapple extract with titrated bromelain (Brome-Inf®) and purified bromelain on pain, swelling, trismus, and quality of life (QoL) following the surgical extraction of the mandibular third molars. Furthermore, this study examined the need for Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) by comparing their effects with a placebo group. This study enrolled 42 individuals requiring the extraction of a single mandibular third molar under local anesthesia. The patients were randomly assigned to receive Brome-Inf®, purified bromelain, or a placebo orally, initiating treatment on the day of surgery and continuing for the next 7 days. The primary outcome measured was the requirement for NSAIDs in the three groups. Pain, swelling, and trismus were secondary outcome variables, evaluated postoperatively at 1, 3, and 7 days. This study also assessed the comparative efficacy of freeze-dried pineapple extract and single-component bromelain. Ultimately, the placebo group showed a statistically higher need for ibuprofen (from days 1 to 7) at the study’s conclusion (p < 0.0001). In addition, reductions in pain and swelling were significantly higher in both the bromelain and pineapple groups (p < 0.0001 for almost all patients, at all intervals) than in the placebo group. The active groups also demonstrated a significant difference in QoL compared to the placebo group (p < 0.001). A non-significant reduction in trismus occurred in the treatment groups compared to the placebo group. Therefore, the administration of pineapple extract titrated in bromelain showed significant analgesic and anti-edema effects in addition to improving QoL in the postoperative period for patients who had undergone mandibular third molar surgery. Moreover, both bromelain and Brome-Inf® supplementation reduced the need for ibuprofen to comparable extents, proving that they are good alternatives to NSAIDs in making the postoperative course more comfortable for these patients. A further investigation with larger samples is necessary to assess the pain-relieving and anti-inflammatory impacts of the entire pineapple phytocomplex in surgical procedures aside from mandibular third molar surgery.
Tipologia CRIS:
03A-Articolo su Rivista
Keywords:
Ananas comosus by-products; analgesic; anti-inflammatory; bromelain; freeze-dried juice; nutraceutical; third molar surgery
Elenco autori:
Colletti, Alessandro; Procchio, Chiara; Pisano, Mariaelena; Martelli, Alma; Pellizzato, Marzia; Cravotto, Giancarlo
Autori di Ateneo:
CRAVOTTO Giancarlo
Link alla scheda completa:
https://iris.unito.it/handle/2318/2047390
Link al Full Text:
https://iris.unito.it/retrieve/handle/2318/2047390/1488920/nutrients-16-00784.pdf
Pubblicato in:
NUTRIENTS
Journal
  • Dati Generali
  • Aree Di Ricerca

Dati Generali

URL

https://www.mdpi.com/2072-6643/16/6/784

Aree Di Ricerca

Settori (18)


LS7_7 - Pharmacology and toxicology - (2024)

PE5_17 - Organic chemistry - (2024)

CIBO, AGRICOLTURA e ALLEVAMENTI - Farmacologia Veterinaria

CIBO, AGRICOLTURA e ALLEVAMENTI - Patologia e malattie degli animali

CIBO, AGRICOLTURA e ALLEVAMENTI - Scienze cliniche veterinarie

MEDICINA, SALUTE e BENESSERE - Disturbi neuropsichiatrici

MEDICINA, SALUTE e BENESSERE - Epidemiologia

MEDICINA, SALUTE e BENESSERE - Malattie neurologiche e neurodegenerative

MEDICINA, SALUTE e BENESSERE - Medicina Rigenerativa e Cellule Staminali

MEDICINA, SALUTE e BENESSERE - Oncologia e Tumori

MEDICINA, SALUTE e BENESSERE - Ricerca Traslazionale e Clinica

MEDICINA, SALUTE e BENESSERE - Trapianti e medicina rigenerativa

PIANETA TERRA, AMBIENTE, CLIMA, ENERGIA e SOSTENIBILITA' - Chimica e Ambiente

SCIENZE DELLA VITA e FARMACOLOGIA - Interazioni tra molecole, cellule, organismi e ambiente

SCIENZE DELLA VITA e FARMACOLOGIA - Molecole bioattive

SCIENZE DELLA VITA e FARMACOLOGIA - Sviluppo del sistema nervoso e plasticità

SCIENZE MATEMATICHE, CHIMICHE, FISICHE - Chimica Organica e Industriale

SCIENZE MATEMATICHE, CHIMICHE, FISICHE - Materiali Avanzati
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